Laura Obici Selected Research

Cytokines

1/2020

A novel knock-in mouse model of cryopyrin-associated periodic syndromes with development of amyloidosis: Therapeutic efficacy of proton pump inhibitors.

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Laura Obici Research Topics

Disease

72	Amyloidosis 04/2024 - 06/2002
24	Transthyretin-Related Hereditary Amyloidosis 04/2024 - 06/2012
20	Polyneuropathies (Polyneuropathy) 04/2024 - 07/2013
18	Immunoglobulin Light-chain Amyloidosis 11/2023 - 05/2003
14	Cardiomyopathies (Cardiomyopathy) 01/2024 - 05/2003
10	Disease Progression 01/2024 - 11/2005
10	Amyloid Plaque 01/2021 - 06/2002
9	Familial Amyloid Neuropathies (Familial Amyloid Polyneuropathy) 01/2022 - 07/2013
8	autosomal dominant familial Periodic fever 09/2023 - 03/2006
8	Fever (Fevers) 01/2020 - 09/2004
7	Necrosis 05/2017 - 08/2011
5	Rare Diseases (Rare Disease) 04/2024 - 12/2005
5	Heart Failure 01/2023 - 05/2003
4	Inflammation (Inflammations) 03/2024 - 01/2017
4	Renal Insufficiency (Renal Failure) 03/2024 - 09/2004
4	Diabetic Neuropathies (Diabetic Neuropathy) 10/2023 - 01/2019
4	Familial Mediterranean Fever (Periodic Disease) 01/2021 - 05/2013
4	Mevalonate Kinase Deficiency 01/2019 - 09/2004
4	Familial Amyloidosis (Hereditary Amyloidosis) 01/2015 - 05/2004
3	Glomerulonephritis 01/2022 - 07/2018
3	Proteinuria 01/2021 - 03/2009
3	Cryopyrin-Associated Periodic Syndromes 01/2020 - 05/2013
3	Hereditary Autoinflammatory Diseases 01/2018 - 09/2004
3	Chronic Kidney Failure (Chronic Renal Failure) 11/2012 - 06/2007
2	Body Weight (Weight, Body) 10/2023 - 09/2023
2	Amyloid Neuropathies (Amyloid Neuropathy) 06/2021 - 06/2020
2	Abdominal Pain (Pain, Abdominal) 01/2021 - 01/2020
2	Pain (Aches) 04/2020 - 09/2013
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2020 - 01/2019
2	Thrombocytopenia (Thrombopenia) 08/2019 - 07/2018
2	Hypogonadism (Hypergonadotropic Hypogonadism) 06/2015 - 07/2007
2	Interstitial Nephritis (Tubulointerstitial Nephritis) 06/2015 - 12/2005
2	Heart Diseases (Heart Disease) 04/2014 - 12/2011
2	Alzheimer Disease (Alzheimer's Disease) 09/2013 - 10/2005
2	Hypoalphalipoproteinemias (Hypoalphalipoproteinemia) 06/2011 - 12/2006
1	Paraproteinemias (Monoclonal Gammopathy) 11/2023
1	Spasm (Spasms) 10/2023
1	Arthralgia (Joint Pain) 10/2023
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2023
1	Paraganglioma (Paragangliomas) 01/2022
1	Pyelonephritis 01/2022
1	Hypotension (Low Blood Pressure) 01/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2021

Drug/Important Bio-Agent (IBA)

54	Prealbumin (Transthyretin)IBA 04/2024 - 05/2004
42	Amyloid (Amyloid Fibrils)IBA 04/2024 - 06/2002
15	Apolipoprotein A-I (Apolipoprotein A1)IBA 09/2023 - 01/2003
15	Proteins (Proteins, Gene)FDA Link 01/2021 - 11/2005
12	Biomarkers (Surrogate Marker)IBA 03/2024 - 12/2011
8	AA amyloidosisIBA 03/2024 - 09/2004
7	patisiranIBA 04/2024 - 01/2019
7	InotersenIBA 12/2022 - 07/2018
7	Colchicine FDA LinkGeneric 01/2021 - 01/2018
7	Dexamethasone (Maxidex)FDA LinkGeneric 04/2014 - 04/2004
6	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2022 - 05/2003
6	Melphalan (Alkeran)FDA LinkGeneric 04/2014 - 04/2004
5	Antisense OligonucleotidesIBA 10/2023 - 08/2019
5	pro-brain natriuretic peptide (1-76)IBA 05/2012 - 05/2003
4	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 11/2023 - 03/2009
4	canakinumab FDA Link 09/2023 - 01/2017
4	Amyloidogenic ProteinsIBA 01/2016 - 06/2002
3	Alkaline PhosphataseIBA 11/2023 - 05/2004
3	LigandsIBA 10/2023 - 06/2021
3	Blood Proteins (Serum Proteins)IBA 01/2018 - 05/2004
3	Thalidomide (Thalomid)FDA Link 01/2012 - 04/2005
2	Messenger RNA (mRNA)IBA 02/2023 - 12/2022
2	TroponinIBA 01/2022 - 12/2011
2	HDL CholesterolIBA 01/2021 - 06/2015
2	Serum Amyloid A Protein (Serum Amyloid A)IBA 01/2021 - 01/2013
2	NLR ProteinsIBA 01/2020 - 01/2018
2	GelsolinIBA 01/2020 - 05/2004
2	tafamidisIBA 03/2019 - 12/2013
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2019 - 04/2015
2	InflammasomesIBA 01/2018 - 01/2018
2	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 07/2007
2	Apolipoprotein A-II (Apolipoprotein A2)IBA 05/2015 - 05/2004
2	ApolipoproteinsIBA 05/2015 - 12/2006
2	Diflunisal (Dolobid)FDA Link 12/2013 - 06/2012
2	Doxycycline (Periostat)FDA LinkGeneric 09/2013 - 06/2012
2	Bortezomib (Velcade)FDA Link 01/2012 - 02/2011
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2011 - 03/2006
2	CholesterolIBA 06/2011 - 12/2006
2	Immunoglobulin M (IgM)IBA 02/2011 - 03/2009
2	Troponin IIBA 11/2010 - 03/2009
1	Immunoglobulins (Immunoglobulin)IBA 11/2023
1	Indicators and Reagents (Reagents)IBA 11/2023
1	dimemorfan (AT 17)IBA 01/2023
1	Extracellular Matrix ProteinsIBA 01/2021
1	Carrier Proteins (Binding Protein)IBA 01/2021
1	Atrial Natriuretic Factor (ANF)IBA 01/2021
1	SynucleinsIBA 01/2021
1	Epidermal Growth Factor (EGF)IBA 01/2021
1	C-Reactive ProteinIBA 01/2021
1	fibulinIBA 01/2021
1	Islet Amyloid PolypeptideIBA 01/2021

Therapy/Procedure

11	Therapeutics 01/2024 - 04/2005
3	RNAi Therapeutics 10/2023 - 01/2019
3	Drug Therapy (Chemotherapy) 02/2023 - 11/2010
3	Liver Transplantation 09/2022 - 02/2013
3	Stem Cell Transplantation 04/2014 - 04/2004
2	Renal Dialysis (Hemodialysis) 09/2013 - 11/2005